13. PSB 2008: Kohala Coast, Hawaii, USA
Russ B. Altman, A. Keith Dunker, Lawrence Hunter, Tiffany Murray, Teri E. Klein (Eds.): Biocomputing 2008, Proceedings of the Pacific Symposium, Kohala Coast, Hawaii, USA, 4-8 January 2008. World Scientific 2008 ISBN 978-981-277-608-2
Beyond Gap Models: Reconstructing Alignments and Phylogenies Under Genomic-Scale Events


Giddy Landan, Dan Graur: Local Reliability Measures from Sets of Co-Optimal Multiple Sequence Alignments. 15-24
Serita M. Nelesen, Kevin Liu, D. Zhao, C. Randal Linder, Tandy Warnow: The Effect of the Guide Tree on Multiple Sequence Alignments and Subsequent Phylogenetic Analysis. 25-36
Amit U. Sinha, Jaroslaw Meller: Sensitivity Analysis for Reversal Distance and Breakpoint Reuse in Genome Rearrangements. 37-48
Computational Challenges in the Study of Small Regulatory RNAs

Jim C. Huang, Brendan J. Frey, Quaid Morris: Comparing Sequence and Expression for Predicting microRNA Targets Using GenMIR3. 52-63
Dang D. Long, Chi Yu Chan, Ye Ding: Analysis of Microrna-Target Interactions by a Target Structure Based Hybridization Model. 64-74
Vladimir Vacic, Hailing Jin, Jian-Kang Zhu, Stefano Lonardi: A Probabilistic Model for Small RNA Flowgram Matching. 75-86
Computational Tools for Next-Generation Sequencing Applications

Benjarath Phoophakdee, Mohammed Javeed Zaki: TRELLIS+: An Effective Approach for Indexing Genome-Scale Sequences Using Suffix Trees. 90-101
Cristian Coarfa, Aleksandar Milosavljevic: Pash 2.0: Scaleable Sequence Anchoring for Next-Generation Sequencing Technologgies. 102-113
Vladimir Jojic, Tomer Hertz, Nebojsa Jojic: Population Sequencing Using Short Reads: HIV as a Case Study. 114-125
Andrew J. Olson, J. Brennecke, A. A. Aravin, G. J. Hannon, Ravi Sachidanandam: Analysis of Large-Scale Sequencing of Small RNAs. 126-136
Knowledge-Driven Analysis and Data Integration for High-Throughput Biological Data

Vincent J. Carey, Jeff Gentry, Deepayan Sarkar, Robert Gentleman, S. Ramaswamy: SGDI: System for Genomic Data Integration. 141-152
Jayesh Pandey, Mehmet Koyutürk, Wojciech Szpankowski, Ananth Grama: Annotating Pathways of Interaction Networks. 153-165
Anneleen Daemen, Olivier Gevaert, Tijl De Bie, Annelies Debucquoy, Jean-Pascal Machiels, Bart De Moor, Karin Haustermans: Integrating Microarray and Proteomics Data to Predict the Response of Cetuximab in Patients with Rectal Cancer. 166-177
Madhuchhanda Bhattacharjee, Colin C. Pritchard, Peter S. Nelson: A Bayesian Framework for Data and Hypotheses Driven Fusion of High Throughput Data: Application to Mouse Organogenesis. 178-189
Michael A. Province, Ingrid B. Borecki: Gathering the Gold Dust: Methods for Assessing the Aggregate Impact of Small Effect Genes in Genomic Scans. 190-200
Robert E. Thurman, William Stafford Noble, John A. Stamatoyannopoulos: Multi-Scale Correlations in Continuous Genomic Data. 201-215
Habtom W. Ressom, Rency S. Varghese, Lenka Goldman, Christopher A. Loffredo, Mohamed Abdel-Hamid, Zuzana Kyselova, Yehia Mechref, Milos V. Novotny, Radoslav Goldman: Analysis of MALDI-TOF Spectrometry Data for Detection of Glycan Biomarkers. 216-227
Molecular Bioinformatics for Diseases: Protein Interactions and Phenomics
Yves A. Lussier, Younghee Lee, Predrag Radivojac, Yanay Ofran, Marco Punta, Atul J. Butte, Maricel G. Kann: Session Introduction. 228-230
Gil Alterovitz, Michael Xiang, Jonathan Liu, Amelia Chang, Marco Ramoni: System-Wide Peripheral Biomarker Discovery Using Information Theory. 231-242
David P. Chen, Susan C. Weber, Philip S. Constantinou, Todd A. Ferris, Henry J. Lowe, Atul J. Butte: Novel Integration of Hospital Electronic Medical Records and Gene Expression Measurements to Identify Genetic Markers of Maturation. 243-254
Haiyan Hu, Xiaoman Shawn Li: Networking Pathways Unveils Association Between Obesity and Non-Insulin Dependent Diabetes Mellitus. 255-266
Liviu Badea: Extracting Gene Expression Profiles Common to Colon and Pancreatic Adenocarcinoma Using Simultaneous Nonnegative Matrix Factorization. 267-278
O. Gaevert, Steven Van Vooren, Bart De Moor: Integration of Microarray and Textual Data Improves the Prognosis Prediction of Breast, Lung, and Ovarian Cancer Patients. 279-290
Padmavati Sridhar, Bin Song, Tamer Kahveci, Sanjay Ranka: Mining Metabolic Networks for Optimal Drug Targets. 291-302
Rohit Singh, Jinbo Xu, Bonnie Berger: Global Alignment of Multiple Protein Interaction Networks. 303-314
Sun Kim, Meng Li, Hyun-il Henry Paik, Kenneth P. Nephew, Huidong Shi, Robin Kramer, Dong Xu, Tim Hui-Ming Huang: Predicting DNA Methylation Susceptibility Using CpG Flanking Sequences. 315-326
Multiscale Modeling and Simulation: From Molecules to Cells to Organisms?
Jung-Chi Liao, Jeff Reinbolt, Roy Kerckhoffs, Anushka Michailova, Peter W. Arzberger: Session Introduction. 327-331
Dariya S. Glazer, Randall J. Radmer, Russ B. Altman: Combining Molecular Dynamics and Machine Learning to Improve Protein Function Recognition. 332-343
Youyong Li, William A. Goddard III: Prediction of the Structure of G-Protein Coupled Receptors and of Bound Ligands with Applications for Drug Design. 344-353
Hilary DeRemigio, Peter Kemper, M. Drew Lamar, Gregory D. Smith: Markov Chain Models of Coupled Intracellular Calcium Channels: Kronecker Structured Representations and Benchmark Stationary Distribution Calculations. 354-365
John Jeremy Rice, Yuhai Tu, Corrado Poggesi, Pieter P. deTombe: Spatially-Compressed Cardiac Myofilament Models Generate Hysteresis that Is Not Found in Real Muscle. 366-377
Joost Lumens, Tammo Delhaas, Borut Kirin, Theo Arts: Modeling Ventricular Interaction: A Multiscale Approach from Sarcomere Mechanics to Cardiovascular Systems Hemodynamics. 378-389
Frank B. Sachse, Eleonora Savio-Galimberti, Joshua I. Goldhaber, John H. B. Bridge: Sub-Micrometer Anatomical Models of the Sarcolemma of Cardiac Myocytes Based on Confocal Imaging. 390-401
Shatam Agarwal, Jaijeet S. Roychowdhury: Efficient Multiscale Simulations of Circadian Rhythms Using Automated Phase Macomodelling Techniques. 402-413
John H. Gennari, Maxwell Lewis Neal, Brian E. Carlson, Daniel L. Cook: Integration of Multi-Scale Biosimulation Models via Light-Weight Semantics. 414-425
Protein-Nucleic Acid Interactions: Integrating Structure, Sequence, and Function
Martha L. Bulyk, Ernest Fraenkel, Alexander J. Hartemink, Yael Mandel-Gutfreund: Session Introduction. 438-440
Rachel Patton McCord, Martha L. Bulyk: Functional Trends in Structural Classes of the DNA Binding Domains of Regulatory Transcription Factors. 441-452
Raluca Gordân, Alexander J. Hartemink: Using DNA Duplex Stability Information for Transcription Factor Binding Site Discovery. 453-464
Wei Pan, Peng Wei, Arkady B. Khodursky: A Parametric Joint Model of DNA-Protein Binding, Gene Expression and DNA Sequence Data to Detect Target Genes of a Transcription Factor. 465-476
Christopher Kauffman, George Karypis: An Analysis of Information Content Present in Protein-DNA Interactions. 477-488
Richard W. Lusk, Michael B. Eisen: Use of an Evolutionary Model to Provide Evidence for a Wide Heterogenity of Required Affinities Between Transcription Factors and Their Binding Sites in Yeast. 489-500
Jae-Hyung Lee, Michael Hamilton, Colin Gleeson, Cornelia Caragea, Peter Zaback, Jeffry D. Sander, Li C. Xue, Feihong Wu, Michael Terribilini, Vasant Honavar, Drena Dobbs: Striking Similarities in Diverse Telomerase Proteins Revealed by Combining Structure Prediction and Machine Learning Approaches. 501-512
Tiling Microarray Data Analysis Methods and Algorithms

Pei Fen Kuan, Hyonho Chun, Sündüz Keles: CMARRT: A Tool of Analysis of CHIP-chip Data from Tiling Arrays by Incorporating the Correlation Structure. 515-526
Georg Zeller, Stefan R. Henz, Sascha Laubinger, Detlef Weigel, Gunnar Rätsch: Transcript Normalization and Segmentation of Tiling Array Data. 527-538
Timothy Danford, P. Alexander Rolfe, David K. Gifford: GSE: A Comprehensive Database System for the Representation, Retrieval, and Analysis of Microarray Data. 539-550
Translating Biology: Text Mining Tools That Work

Beatrice Alex, Claire Grover, Barry Haddow, Mijail Kabadjor, Ewan Klein, Michael Matthews, Stuart Roebuck, Richard Tobin, Xinglong Wang: Assisted Curation: Does Text Mining Really Help?. 556-567
Anna Divoli, Marti A. Hearst, Michael A. Wooldridge: Evidence for Showing Gene/Protein Name Suggestions in Bioscience Literature Search Interfaces. 568-579
Joel Dudley, Atul J. Butte: Enabling Integrative Genomic Analysis of High Impact Human Diseases Through Text Mining. 580-591
Phoebe M. Roberts, William S. Hayes: Information Needs and the Role of Text Mining in Drug Development. 592-603
Scott Brady, Hagit Shatkay: EpiLoc: A (Working) Text-Based System for Predicting Protein Subcellular Location. 604-615
Yoshinobu Kano, Ngan Nguyen, Rune Sætre, Kazuhiro Yoshida, Yusuke Miyao, Yoshimasa Tsuruoka, Yuichiroh Matsubayashi, Sophia Ananiadou, Jun'ichi Tsujii: Filling the Gaps Between Tools and Users: A Tool Comparator, Using Protein-Protein Interactions as an Example. 616-627
Xinglong Wang, Michael Matthews: Comparing Usability of Matching Techniques for Normalising Biomedical Named Entities. 628-639
J. Gregory Caporaso, Nita Deshpande, J. Lynn Fink, Philip E. Bourne, K. Bretonnel Cohen, Lawrence Hunter: Intrinsic Evaluation of Text Mining Tools May Not Predict Performance on Realistic Tasks. 640-651
Robert Leaman, Graciela Gonzalez: BANNER: An Executable Survey of Advances in Biomedical Named Entity Recognition. 652-663



